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It raises insulin, lowers glucagon, and slows gastric emptying

The two most notable ones being: Preventing enzymatic cleavage replacing Ala2 with -aminoisobutyric acid (Aib) to remove the DPP-4 cleavage site and avoid degradation

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First, treatment allocation was not randomized, raising the potential for residual confounding despite extensive pretreatment covariate adjustment through propensity score matching

It is currently available only within clinical trials, and any use outside a trial setting would be considered off-label and is not recommended

The hormones themselves are bio-identicalstructurally identical to what your body produces naturally